The Interpretation of Hepatitis Viral Load Test.

What is HBV Quant.?

Hepatitis B Virus - Viral Load, Quantitative test assesses the level of viral infection in the body. It measures the amount of viral DNA in the blood during the infection. Generally, this test is recommended to check the efficacy of hepatitis B treatment. Hepatitis B virus spreads mainly through body fluids or unsafe sexual intercourse.

Mostly the symptoms of infection fade on their own after 4-8 weeks. However, in some cases, uncontrolled levels of HepB viral load can lead to chronic hepatitis infection and liver cirrhosis.

Why is HBV Quant. done?

The Hepatitis B Virus - Viral Load, Quantitative test is done:

For the management of patients with chronic hepatitis B infection and currently on antiviral therapy
For the diagnosis of hepatitis B for baseline values and during the course of therapy to assess the treatment response.

What does HBV Quant. Measure?

The Hepatitis B Virus - Viral Load, Quantitative test measures the amount of hepatitis B in a blood sample. This test helps determine whether Hepatitis B Virus (HBV) is getting reproduced in the liver. If HBV viral load is greater than 20,000 international units per milliliter (IU/mL) in a person with detectable Hepatitis B envelope antigen (HBeAg) then it indicates that the virus is active and has the greatest potential to cause damage to the liver. Similarly, if HBV viral load is greater than 2,000 IU/mL in HBeAg-negative chronic hepatitis B patients then it indicates that the virus is active and has the potential to cause damage to the liver. If the HBV viral load is above these numbers, treatment is considered necessary.

Interpreting HBV Quant. results

Interpretations

RESULT in IU/mL	REMARKS
Target not detected	The sample provided does not contain HBV DNA
<20	HBV DNA was detected but below the lower limit of the linear range of the assay. These results should be interpreted with caution
>=20 to < 1.7 x 108	HBV DNA detected within the linear range of the assay
>=1.7 x 108	HBV DNA detected above the linear range of the assay

The linear reporting range of the assay is 20 - 1.7 x 108 IU/mL
Conversion factor: 1 IU/mL = 5.82 copies / mL

Results are categorized into 3 levels

Low or undetectable viral load means that the lab equipment cannot detect it and viral load is less than approximately 300 copies/mL
Moderate levels are about 10,000 – 90,000 copies/mL
High levels indicate quantities over 100,000 copies/mL, which is considered clinically significant

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about HBV Quant.

Comments

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